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1: Post something you have never done that you think many people do. 2: Read the other posts, if you have done that thing, upvote it. If you have not done that thing, downvote it. 3: If you believe the person is lying, call them out on it in a reply. 4: If you are called out, give the full story. 4a: If you see a thread containing the full story, boost the person you think is right and truthful.

Person who has the most upvotes when the thread dies wins.

  • tetris11@lemmy.ml
    2·
    3 months ago

    where does the tolerance come from though? With alcohol it’s very clear that there’s one organ doing the heavy lifting. With weed, I have no idea.

    To each their own though, not trying to pressure anybody.

    Of course! Likewise, I’m not trying to shame anyone for picking weed over beer. Each to their own

    Edit: Apparently it’s “CB1 receptor density” in your brain that handles the tolerance.

    • WeirdGoesPro@lemmy.dbzer0.com
      2·
      3 months ago

      Indeed, a lot of drugs that are non toxic have tolerance created in the brain, while more toxic drugs have to get processed by the kidneys and liver, which is why the functioning of those organs contributes to tolerance.

    • deranger@sh.itjust.works
      2·
      3 months ago

      With alcohol it’s very clear that there’s one organ doing the heavy lifting

      It’s not your liver, it’s your GABA receptors downregulating that gives you a tolerance. Your liver helps with the duration and hangover but the lower peak intoxication is mediated by the receptors. Likewise with cannabis, your THC receptors downregulate to give you a weed tolerance. It is also processed by the liver.