More changes would be needed than direct uniform scaling - .22lr is rimfire, whereas .45acp is centerfire, for example, and their aspect ratios are different. The mass and strength of uniformly scaled-down parts also might not match the recoil and pressure provided by the smaller round, and might result in failure to reliably cycle the action or the gun bursting if the mismatch is too much.
The top issue from this similar joke repo I feel sums up the entire industry right now: https://github.com/rhettlunn/is-odd-ai